T-cell recognition of a cross-reactive antigen(s) in erythrocyte stages of Plasmodium falciparum and Plasmodium yoelii: inhibition of parasitemia by this antigen(s)

In the current study, we investigated the presence of a cross-reactive antigen(s) in the erythrocyte stage from Plasmodium yoelii (265 BY strain) and Plasmodium falciparum through recognition by T cells primed in vivo with antigens from each of these parasites. BALB/c mice are naturally resistant to P. falciparum but are susceptible to P. yoelii infection. Mice that had recovered from P. yoelii primary infection became resistant to a second infection. A higher in vitro proliferative response to a soluble blood stage preparation of P. falciparum was observed in splenic cells from immune animals than in those from mice with a patent P. yoelii infection. The antigen-induced proliferative response was enhanced when animals were exposed to a secondary infection. Animals exposed to a challenge infection were treated with anti-CD4 or anti-CD8 monoclonal antibodies to deplete the corresponding subset of T cells. There was a marked diminution in P. falciparum antigen-induced proliferative response in the total splenic cell populations from CD8-depleted but not from CD4-depleted mice. In CD8-depleted and nondepleted animals, the antigen-induced proliferation in the total cell populations was markedly lower than in the T-cell-rich populations, indicating inhibitory activities of B cells and/or macrophages. There was no such difference in the stimulation between total and T-enriched cell populations from CD4-depleted animals. Flow cytometry analysis demonstrated the presence of an almost equal percentage of CD8+ (59.6%) and CD4+ (64%) T cells in the spleen preparations following in vivo depletion of CD4- and CD8-bearing T cells, respectively. When cultured with P. yoelii blood stage antigen, splenocytes from animals immunized with P. falciparum antigen displayed a significant proliferative response which was markedly diminished by treatment with anti-Thy-1.2 antibody plus complement. Animals immunized with P. falciparum antigen and then challenged with P. yoelii blood stage parasites displayed about a 50% lower level of parasitemia. These results demonstrated the existence of a cross-reactive antigen(s) between a murine and a human Plasmodium species, as determined from both in vivo and in vitro biological assays, and indicated the reactivity of mainly CD8+ T cells with this antigen.     

PbS and CdS Quantum Dot‐Sensitized Solid‐State Solar Cells: “Old Concepts,New Results”

Lead sulfide (PbS) and cadmium sulfide (CdS) quantum dots (QDs) are prepared over mesoporous TiO₂ films by a successive ionic layer adsorption and reaction (SILAR) process. These QDs are exploited as a sensitizer in solid‐state solar cells with 2,2′,7,7′‐tetrakis(N,N‐di‐p‐methoxyphenylamine)‐9,9′‐spirobifluorene (spiro‐OMeTAD) as a hole conductor. High‐resolution transmission electron microscopy (TEM) images reveal that PbS QDs of around 3 nm in size are distributed homogeneously over the TiO₂ surface and are well separated from each other if prepared under common SILAR deposition conditions. The pore size of the TiO₂ films and the deposition medium are found to be very critical in determining the overall performance of the solid‐state QD cells. By incorporating promising inorganic QDs (PbS) and an organic hole conductor spiro‐OMeTAD into the solid‐state cells, it is possible to attain an efficiency of over 1% for PbS‐sensitized solid‐state cells after some optimizations. The optimized deposition cycle of the SILAR process for PbS QDs has also been confirmed by transient spectroscopic studies on the hole generation of spiro‐OMeTAD. In addition, it is established that the PbS QD layer plays a role in mediating the interfacial recombination between the spiro‐OMeTAD⁺ cation and the TiO₂ conduction band electron, and that the lifetime of these species can change by around 2 orders of magnitude by varying the number of SILAR cycles used. When a near infrared (NIR)‐absorbing zinc carboxyphthalocyanine dye (TT1) is added on top of the PbS‐sensitized electrode to obtain a panchromatic response, two signals from each component are observed, which results in an improved efficiency. In particular, when a CdS‐sensitized electrode is first prepared, and then co‐sensitized with a squarine dye (SQ1), the resulting color change is clearly an addition of each component and the overall efficiencies are also added in a more synergistic way than those in PbS/TT1‐modified cells because of favorable charge‐transfer energetics.     

Exploiting Context-Awareness in Cluster-Based Wireless Sensor Networks

Most of the wireless sensor network's (WSN's) applications require getting accurate information as well as uninterrupted, prolonged service life. Among the constituting elements of WSN, an efficient routing protocol plays a significant role in attaining such service requirements. In this article, an energy efficient routing protocol, context-aware clustering hierarchy (CACH), is proposed where cluster formation is based on the context of the environment. Moreover, a technique is utilized to avoid similar data traffic across the network. The performance in the simulation shows energy saving which ensures prolonged service life. Copyright © 2009 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.     

L(j, k)-Labelings of Kronecker Products of Complete Graphs

For positive integers j ges k, an L(j, k)-labeling of a graph G is an integer labeling of its vertices such that adjacent vertices receive labels that differ by at least j and vertices that are distance two apart receive labels that differ by at least k. We determine lambda^j _k(G) for the case when G is a Kronecker product of finitely many complete graphs, where there are certain conditions on j and k. Areas of application include frequency allocation to radio transmitters.     

PSO-based Parameter Tuning for a Two-Degree-of-Freedom IMC Scheme and Its Application to Paper Basis Weight Control

Basis weight is an important indicator for evaluating paper quality and a major factor directly affecting the economic benefits of enterprises. Focusing on the large time-delay, time-varying, and nonlinear characteristics of a basis weight control system, a two-degree-of-freedom(TDF) internal model control(IMC) method based on a particle swarm optimization(PSO) algorithm was proposed. The method took the integral of time multiplied by the absolute error(ITAE) as the objective function, and the PSO algorithm was used to optimize the time constant of the tuning IMC filter. The simulation results for the control system under the proposed TDF-IMC method based on the PSO algorithm demonstrate good set-point tracking performance, strong anti-interference capabilities, and good robustness properties. The application results revealed that the basis weight fluctuation range of the paper was ±2 g/m~2, which significantly improved both the control quality and the product quality.     

Synthesis of polymer/MWCNT nanocomposite catalyst supporting materials for high-temperature PEM fuel cells

In this study, the polymer/MWCNT nanocomposites were synthesized from the pristine MWCNT and polymer binders using functionalization with solution processing methods. The synthesized polymer/MWCNT nanocomposites exhibited high specific surface areas than the pristine MWCNT. The MWCNT/Nafion nanocomposite attributed to the maximum peak current at 5.795 × 10^?5 (A) while the peak current of MWCNT/PBI was obtained at 3.662 × 10^?5 (A). Moreover, polymer/MWCNT based electrocatalysts performed better electrochemical activity because of polymers binders can assist electrochemical interaction using the high surface areas of the catalyst supporting material. Also, the MEAs fabricated using the hot pressing method, while the acid doped PBI membrane sandwiched between the electrodes. The fabricated MEAs were successfully demonstrated in a single cell and found capable of measuring a maximum power density of 112.10 mW/cm² under 150 °C temperature. In conclusion, the synthesized catalyst-supporting materials enhanced the electrochemical activity and catalyst stability which fulfilling the main objective of this study.     

Characterization of Slag Flow in Fixed Packed Bed of Coke Particles

Metallurgical and Materials Transactions B - The static and dynamic holdups of liquid slag flow in a packed coke bed were investigated at a temperature of 1723 K by using the...     

A 0D Lead‐Free Hybrid Crystal with Ultralow Thermal Conductivity

Organic–inorganic hybrid materials are of significant interest owing to their diverse applications ranging from photovoltaics and electronics to catalysis. Control over the organic and inorganic components offers flexibility through tuning their chemical and physical properties. Herein, it is reported that a new organic–inorganic hybrid, [Mn(C₂H₆OS)₆]I₄, with linear tetraiodide anions exhibit an ultralow thermal conductivity of 0.15 ± 0.01 W m^?1 K^?1 at room temperature, which is among the lowest values reported for organic–inorganic hybrid materials. Interestingly, the hybrid compound has a unique 0D structure, which extends into 3D supramolecular frameworks through nonclassical hydrogen bonding. Phonon band structure calculations reveal that low group velocities and localization of vibrational energy underlie the observed ultralow thermal conductivity, which could serve as a general principle to design novel thermal management materials.     

Dynamic energy efficient routing protocol in wireless sensor networks

Wireless Networks - Currently, IEEE 802.11 standard for ad-hoc wireless mode is inadequate for multi-hop network. Recent efforts for the advancement of 802.11 standards, such as 11e for QoS support...     

Further slot antenna miniaturization and bandwidth enhancement

In this work, antenna miniaturization using slits and metallic strips fed by microstrip line has been demonstrated. It has been noticed that slot antenna fed by microstrip line provides more miniaturization and in some cases enhanced bandwidth in comparison with the slot antenna fed by other feeding mechanism, keeping the same length and width of the radiating slots, slits and metallic strips. We have achieved 51.67% reduction in resonant frequency and 74.72% improvement in ?10 dB bandwidth compared with 37.73% and no bandwidth improvement of either side slits loaded slot antenna topology. Further, it has been shown 63.52% reduction in resonant frequency and 2.23% improvement in ?10 dB bandwidth in comparison with 42.33% reduction in resonant frequency of only one side slits loaded slot antenna topology. The current work highlighted not only greater miniaturization and enhanced bandwidth but also almost unperturbed radiation pattern compared to reference antenna topology and low cross‐pol level even slot antenna loaded by only one side slits, which was not demonstrated in earlier works.